杨瑞阁，女，太阳城集团特聘教授，博士生导师，太阳城集团“青年优秀人才”。2005-2012年本硕就读于西北农林科技大学，2012-2015年在康龙化成（西安）新药技术有限公司从事药物研发工作，2018年博士毕业于西北农林科技大学化学生物学专业。主要从事中药活性物质的发现、结构优化、生物活性评价及其作用机制研究；药用植物资源的可持续利用与保护。主持中国自然科学基金青年科学基金、中国博士后面上、河南省重点研发与推广专项（科技攻关）等项目。以第一/通讯作者在J. Med. Chem.、Eur. J. Med. Chem.、Chinese Chem. Let.、J. Agri. Food Chem.等SCI期刊发表论文20多篇，其中中科院1区Top 16篇，ESI高被引论文1篇。
1. Xu T.1, Yan X. T.1, Kang A. Y., Yang L. H., Li X. H., Tian Y., Yang R. G.*, Qin S. S.*, Guo Y.* Development of membrane-targeting fluorescent 2-phenyl-1H- phenanthro[9,10-d]imidazole-antimicrobial peptide mimic conjugates against methicillin-resistant Staphylococcus aureus. Journal of Medicinal Chemistry, 2024, https://doi.org/10.1021/acs.jmedchem.4c00436.
2. Yao, H., Cui, L. P., Liu, H., Li, X. Y., Shen, L., Yang, R. G.*, Qin, S. S.*., Guo, Y.* Quinoline-based anti-MRSA agents: Current development, structure-activity relationships, and mechanisms. Chinese Chemical Letters, 2024, 108511.
3. Yang R. G.1, Cheng W. Q.1, Huang M. J., Xu T., Zhang M. M., Liu J. F., Qin S. S., Guo Y.* Novel membrane-targeting isoxanthohumol-amine conjugates for combating methicillin- resistant Staphylococcus aureus (MRSA) infections. European Journal of Medicinal Chemistry, 2024, 268, 116274.
4. Cheng, W. Q., Xu, T., Cui, L. P., Xue, Z. H., Liu, J. F., Yang, R. G.*, Qin, S. S.*, Guo, Y.* Discovery of Amphiphilic Xanthohumol Derivatives as Membrane- Targeting Antimicrobials against Methicillin-Resistant Staphylococcus aureus. Journal of Medicinal Chemistry, 2023, 66(1), 962-975.
5. Yang, R. G.1, Hou, E. H.1, Cheng, W. Q., Yan, X. T., Zhang, T. T., Li, S. H., Yao, H.*, Liu, J. F.*, Guo, Y.*Membrane-targeting neolignan-antimicrobial peptide mimic conjugates to combat methicillin-resistant Staphylococcus aureus (MRSA) infections. Journal of Medicinal Chemistry, 2022, 65(24), 16879-16892.
6. Liu, Z. Y.1, Han, M. Y.1, Yan, X. T., Cheng, W. Q., Tang, Z. S., Cui, L. P., Yang, R. G.*, Guo, Y.* Design, synthesis, and biological evaluation of novel osthole- based isoxazoline derivatives as insecticide candidates. Journal of Agricultural and Food Chemistry. 2022, 70, 7921−7928.
7. Guo Y.*, Hou E. H., Ma N. N., Liu Z. Y., Fan J. P., Yang R. G.* Discovery, biological evaluation and docking studies of novel N -acyl-2-aminothiazoles fused (+)-nootkatone from Citrus paradisi Macf. as potential α-glucosidase inhibitors. Bioorganic Chemistry, 2020, 104, 104294.
招生方向：药学、天然药物化学
热烈欢迎对中药活性成分提取分离、天然产物结构优化、小分子药物合成、有机化学、抗感染药物材料及抗感染药理感兴趣的博士后、博士、硕士研究生以及本科生加入本课题组！
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